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Inositol is a sugar made in the body and found in foods. It can be found in nine forms. Myo-inositol and D-chiro-inositol are most common in supplements. Because supplementation with inositol can increase insulin sensitivity and help improve fasting glucose and postprandial glycemic control, [7] [8] inositol might help prevent and/or treat diabetes. One type of diabetes for which the role of inositol has been widely studied is gestational diabetes, a condition characterized by abnormal glucose tolerance and high blood sugar during pregnancy. Meta-analyses show that supplementation with inositol during pregnancy might reduce the incidence of gestational diabetes and related birth complications. [9] [10] [11] However, further high-quality randomized controlled trials are needed to determine whether inositol is efficacious in the treatment of gestational diabetes. [12] Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I Role of Inositols and Inositol Phosphates in Energy Metabolism. Molecules. (2020-Nov-01)
When taken by mouth: Inositol is possibly safe for most adults when used for up to 10 weeks. It might cause diarrhea, gas, and nausea in some people.
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Join my PCOS Monthly Meal Planning Service here. This service includes hundreds of PCOS recipes within a pre-populated, yet customizable meal plan. It's designed to save you time and help you apply a PCOS diet. Weight - M Nordio, E Proietti The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone Eur Rev Med Pharmacol Sci. (2012 May) Kiani AK, Paolacci S, Calogero AE, Cannarella R, Di Renzo GC, Gerli S, Della Morte C, Busetto GM, De Berardinis E, Del Giudice F, Stuppia L, Facchinetti F, Dinicola S, Bertelli M From Myo-inositol to D-chiro-inositol molecular pathways. Eur Rev Med Pharmacol Sci. (2021-Mar) Hirschberg AL. Polycystic ovary syndrome, obesity and reproductive implications. Womens Health (Lond Engl). 2009 Sep; 5(5):529-40
M.G., et al., Effects of short-term treatment with metformin on serum concentrations of homocysteine, folate and vitamin B12 in type 2 diabetes mellitus: a randomized, placebo-controlled trial. J Intern Med, 2003. 254(5): p. 455-63. For product recommendations and dosages based on your specific health goals, take this PCOS inositol quiz. What Is Inositol? D., et al., The importance of folate, vitamins B6 and B12 for the lowering of homocysteine concentrations for patients with recurrent pregnancy loss and MTHFR mutations. Reprod Toxicol, 2017. 72: p. 159-163. Monastra G, Vucenik I, Harrath AH, et al. PCOS and inositols: controversial results and necessary clarifications. basic differences between d-chiro and myo-inositol. Front Endocrinol. 2021;12:269. doi:10.3389/fendo.2021.660381Uncover the truth about popular supplements like creatine, turmeric, garlic, zinc, melatonin, and more. Plus, we’ll debunk myths surrounding multivitamins, testosterone boosters, and immune supplements. PCOS is a syndrome that occurs when a woman’s body produces abnormally high amounts of certain hormones. One six-month study in 80 postmenopausal women with metabolic syndrome found that 4 grams per day of inositol improved insulin sensitivity, blood pressure and cholesterol levels more than a placebo ( 10).
Many meta-analyses now show that inositol supplements are as effective as metformin for a range of biomarkers. These include insulin sensitization, testosterone levels, body mass index, and menstrual frequency [ 46, 47]. R.Z., et al., Risk factors of vitamin B(12) deficiency in patients receiving metformin. Arch Intern Med, 2006. 166(18): p. 1975-9. Cheang KI, Baillargeon JP, Essah PA, et al. Insulin-stimulated release of D-chiro-inositol-containing inositol phosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Metabolism. 2008 Oct; 57(10): 1390-7. What is the best myo-inositol supplement for fertility? Myo-inositol is a commodity supplement. Most brands should be capable of delivering similar clinical results. But independent studies have observed significant issues with product quality and labeling accuracy [ 62]. It’s advised to only use trusted suppliers like those mentioned above.
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Metformin for PCOS is a widely used treatment. But side effects are common [ 33, 34]. Metformin is also known to deplete nutrients with long-term use [ 35-43].
Jamilian H, Jamilian M et al. Comparison of myo-inositol and metformin on mental health parameters and biomarkers of oxidative stress in women with polycystic ovary syndrome: a randomised, double-blind, placebo-controlled trial. J Psychosom Obstet Gynaecol. 2018 Dec; 39(4): 307-314 Another small study reported that 6 grams per day improved depression in 9 of 11 participants ( 23). A number of recent studies have found myo-inositol to be an effective support in PCOS, in part due to its ability to improve insulin sensitivity, restore hormonal balance, improve menstrual regularity, reduce hyperandrogenism and influence ovarian function. Research has also demonstrated fertility-improving effects of myo-inositol among women with PCOS; and since the syndrome is the leading cause of female infertility, these results are particularly encouraging. 13-22 Benjamin J, Agam G, et al. Inositol treatment in psychiatry. Psychopharmacol Bull. 1995;31(1):167-75.Currently, the evidence to support using myo-inositol in PCOS is rapidly emerging and promising particularly with regard to hormonal, ovulatory and metabolic benefits. As with many aspects of nutrition-based interventions however, the research is still considered to be limited by small study group sizes. According to the International PCOS Network, inositol (in any form) should be considered an experimental therapy in PCOS, “as this agent is freely available as a nutritional supplement, at low to moderate cost and appears to have a limited side effect profile, it may warrant consideration for use despite limited and low quality evidence. As with other supplements or complementary therapies, women taking this agent are encouraged to advise their health care team.” 36 Glycemic Control - Miñambres I, Cuixart G, Gonçalves A, Corcoy R Effects of inositol on glucose homeostasis: Systematic review and meta-analysis of randomized controlled trials Clin Nutr. (2019 Jun) Myo-inositol is one of nine different types of inositol. It is a naturally occurring substance produced in the human body from glucose, although it is not a sugar. Better described as a ‘vitamin-like’ substance, myo-inositol is often considered to be a member of the B complex group of vitamins. However, because it is produced by the body in amounts considered sufficient to support health, it is not officially termed an essential nutrient. In addition to the body’s own production from glucose, myo-inositol is also found naturally in many foods such as organ meats, fruit, grains, nuts and beans.
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